Policy Updates

On November 21, 2025The Global Fund held its Eighth Replenishment Summit, in Johannesburg, South Africa, co-hosted by the governments of South Africa and the UK on the margins of the G20 Leaders' Summit, securing US$11.3 billion in pledges to sustain the fight against AIDS, tuberculosis, and malaria.

Partners from more than 30 countries pledged support to save lives and strengthen systems for health, marking the first replenishment held on African soil. The summit demonstrated global solidarity despite fiscal tightening, conflict, and global uncertainty, though total pledges fell short of the ambitious target set in the Investment Case and several donors had yet to confirm their pledges.

The US, the Global Fund's largest donor, committed US$4.6 billion. The UK pledged GBP850 million (US$1.1 billion), while Germany confirmed EUR1 billion (US$1.2 billion) and Canada pledged CAD1.02 billion (US$723 million). France noted that its support remained unchanged. Spain increased its pledge to EUR145 million (US$167 million), Italy pledged EUR150 million (US$173 million), the Netherlands contributed EUR146 million (US$169 million), and additional pledges came from many other donors. South Africa committed US$37 million, including US$10 million from the private sector. African countries made solidarity commitments totaling US$52 million. G20 member states reached US$9 billion in commitments.

Within the private sector, the Gates Foundation pledged US$912 million, the Children's Investment Fund Foundation pledged US$135 million, and (RED) committed US$75 million. Overall, private sector support reached US$1.3 billion.

On September 10, 2024, the European Commission’s HERA facilitated the delivery of nearly 100,000 mpox vaccine doses to the DRC, marking the first shipment of its kind to the country.

An additional 100,000 doses are expected soon, contributing to the total of 215,000 vaccines pledged to combat the mpox outbreak in Africa. Team Europe will donate a total of 566,500 mpox vaccine doses to affected African countries, with contributions from France, Germany, Spain, Malta, Portugal, Luxembourg, Croatia, Austria, and Poland.

The EC also released EUR1 million (US$1 million) in humanitarian assistance to support care, prevention, epidemiological surveillance, risk communication and distribution of kits in the DRC.